Article

Process engineering of biopharmaceutical production in moss bioreactors via model-based description and evaluation of phytohormone impact

2021-12-21

Abstract excerpt

The moss Physcomitrella is an interesting production host for recombinant biopharmaceuticals. Here we produced MFHR1, a synthetic complement regulator which has been proposed for the treatment of diseases associated to the complement system as part of human innate immunity. We studied the impact of different operation modes for the production process in 5 L stirred-tank photobioreactors. The total amount of recomb...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 77768e48-62c1-5b93-9e51-994701d86a09
DOI: 10.1101/2021.12.19.473340

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Process engineering of biopharmaceutical production in moss bioreactors via model-based description and evaluation of phytohormone impactDOI 10.1101/2021.12.19.473340Read

Multifactorial analysis of terminator performance on heterologous gene expression in PhyscomitrellaSemantic proximity Read

Biosynthetic Mechanisms of Plant Chlorogenic Acid from a Microbiological PerspectiveSemantic proximity Read

Production of biologically active recombinant human factor H in Physcomitrella.Semantic proximity Read

Bacillus megaterium JPR68 modulates soil nitrogen uptake and suppress collar rot in Bhut Jolokia by triggering systemic resistanceSemantic proximity Read

The moss Physcomitrella patens: methods and tools from cultivation to targeted analysis of gene function.Semantic proximity Read

Enhancement of acarbose production by rational genetic engineering and process optimization in Actinoplanes sp. SIPI12-34Semantic proximity Read

Gene editing of <i>Nicotiana benthamiana</i> architecture for space-efficient production of recombinant proteins in controlled environmentsSemantic proximity Read

Regulatory role of UvrY in adaptation of Photorhabdus luminescens growth inside the insect.Semantic proximity Read

Pantoea ananatis carotenoid production confers toxoflavin tolerance and is regulated by Hfq-controlled quorum sensingSemantic proximity Read

Enhancement of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) production in the transgenic Arabidopsis thaliana by the in vitro evolved highly active mutants of polyhydroxyalkanoate (PHA) synthase from Aeromonas caviae.Semantic proximity Read

Impacts of pr-10a overexpression at the molecular and the phenotypic level.Semantic proximity Read

Engineering central metabolic pathways for high-level flavonoid production in Escherichia coli.Semantic proximity Read