Article
IL6/sIL6R REGULATES TNFα-INFLAMMATORY RESPONSE IN SYNOVIAL FIBROBLASTS THROUGH MODULATION OF TRANSCRIPTIONAL AND POST-TRANSCRIPTIONAL MECHANISMS
2020-10-14
Abstract excerpt
<title>Abstract</title> <p>Introduction: The clinical efficacy of specific interleukin-6 inhibitors has confirmed the central role of IL6 in rheumatoid arthritis (RA). However the local role of IL6, in particular in synovial fibroblasts (SF) as a direct cellular target to IL6/sIL6R signal is not well characterized. The purpose of the study was to characterize the crosstalk between TNFα and IL6/sIL6R signaling to...
Topics
Open a Topic to create a Post that cites this publication.
Identifiers and source
- Literature Corpus work
- 7770113b-c528-56ff-9a42-ea19b093eb09
- DOI
- 10.21203/rs.3.rs-32228/v3