Article

Respiratory Alkalosis Provokes Spike-Wave Discharges in Seizure-Prone Rats

2021-08-15

Abstract excerpt

Hyperventilation reliably provokes seizures in patients diagnosed with absence epilepsy. Despite this predictable patient response, the mechanisms that enable hyperventilation to powerfully activate absence seizure-generating circuits remain entirely unknown. Using the WAG/Rij rat, an established rodent model of absence epilepsy, we demonstrate that absence seizures are highly sensitive to arterial carbon dioxide,...

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Literature Corpus work: 76f0142f-0a0f-59be-8bc6-1a1468d42b6d
DOI: 10.1101/2021.08.15.456408

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