Article
A systematic review and evidence assessment of monogenic gene-disease relationships in human male infertility.
Frontiers in endocrinology - 1 Jan 2025
Zhao Qian, Peng Huifang, Chen Jiali, Zhang Hui, Ma Yujin, Jiang Hongwei
Abstract excerpt
Background: Genetic factors play a significant role in human male infertility, with about 4% of infertile men currently identified with genetic reasons, yet most (60-70%) still lack a definitive diagnosis and remain unexplained. Similar to other medical fields, the advent of next-generation sequencing (NGS) has resulted in the discovery of a growing array of genetic variations in infertility issues affecting both...
Read the complete abstract on PubMedTopics
- Humans
- Male
- Infertility, Male
- Genetic Predisposition to Disease