Article

Short-term oxycodone exposure produces delayed and persistent gut microbiome disruption in mice

2026-05-27

Abstract excerpt

The gut microbiome is a critical part of host homeostasis, yet its resilience following opioid exposure remains poorly understood. While opioid-induced short-term dysbiosis is well documented, the long-term recovery dynamics following oxycodone remain unclear. This study characterized the temporal dynamics of the fecal microbiota in male C57BL/6J mice following a brief 3-day oxycodone regimen (5mg/kg, BID). 16S rR...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 769f984a-b964-59f0-9fbc-2b2d2fb7198d
DOI: 10.64898/2026.05.26.727957

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Short-term oxycodone exposure produces delayed and persistent gut microbiome disruption in miceDOI 10.64898/2026.05.26.727957Read

Dynamics of Gut Microbiota Recovery after Antibiotic Exposure in Young and Old Mice (A Pilot Study)Semantic proximity Read

The Host-Microbiome Response to Hyperbaric Oxygen Therapy in Ulcerative Colitis PatientsSemantic proximity Read

Impact of a Model Used to Simulate Chronic Socio-Environmental Stressors Encountered during Spaceflight on Murine Intestinal MicrobiotaSemantic proximity Read

Pharmacologically Induced Weight Loss Is Associated With Distinct Gut Microbiome Changes In Obese RatsSemantic proximity Read

Differential response to prolonged amoxicillin treatment: long-term resilience of the microbiome versus long-lasting perturbations in the gut resistomeSemantic proximity Read

Regulation of Life Span by The Gut Microbiota in The Short-Lived African Turquoise KillifishSemantic proximity Read

General Anesthesia Alters the Diversity and Composition of the Intestinal Microbiota in MiceSemantic proximity Read

The gut microbiome contributes to somatic morphine withdrawal behavior and implicates a TLR2 mediated mechanismSemantic proximity Read

Repeated sleep disruption in mice leads to persistent shifts in the fecal microbiome and metabolomeSemantic proximity Read

Path-dependent recovery of the gut microbiome after antibiotics emerges from coupled ecological and evolutionary dynamicsSemantic proximity Read

Dietary Supplementation with Omega-3 Polyunsaturated Fatty Acids Reduces Opioid-Seeking Behaviors and Alters the Gut MicrobiomeSemantic proximity Read

Structural changes in the gut microbiome of short-term and long-term medical workers compared to normal controlsSemantic proximity Read