Article

Engineered muscle tissues with enhanced maturation enable the identification of clinically relevant rAAV capsids

2026-01-14

Abstract excerpt

<h4>ABSTRACT</h4> Developing in vitro models that recapitulate both the structure and function of native human tissues is crucial for a better understanding of pathophysiology and for improving the reliability of preclinical studies. Here, we demonstrate that engineered muscle tissues derived from human pluripotent stem cells can serve as an in vitro platform for gene therapy. Recombinant vectors derived from the...

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Literature Corpus work: 75e0faf0-bddb-5b28-93fd-cd7fce24150d
DOI: 10.64898/2026.01.13.699271

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