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Direct Reprogramming of Somatic Cells to Functional Gametes in Planarians via a Novel <em>In Vitro</em> Gametogenesis Protocol

2025-09-15

Abstract excerpt

This study establishes a novel and robust protocol for the direct reprogramming of differentiated somatic cells into functional gamete precursors in the planarian Schmidtea mediterranea, bypassing the need for a pluripotent intermediate state. Through a optimized two-phase in vitro gametogenesis (IVG) protocol involving transient low-dose Yamanaka factor exposure followed by a defined germline-commitment cocktail,...

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Literature Corpus work
757d6cb1-b3d6-54b3-9bcb-4ae8fcc08494
DOI
10.20944/preprints202509.1071.v1
Open publication

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Direct Reprogramming of Somatic Cells to Functional Gametes in Planarians via a Novel <em>In Vitro</em> Gametogenesis ProtocolDOI 10.20944/preprints202509.1071.v1
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