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STRATA: Spatial Regulon Field Theory Reveals Coupling Architecture of Human Skin and Its Homogenization in Melanoma

2026-02-25

Abstract excerpt

Spatial transcriptomics captures gene expression in tissue context, yet current analyses reduce continuous regulatory landscapes to discrete cell clusters, discarding the geometry of intercellular regulation. Here we introduce STRATA (Spatial Transcription-factor Regulatory Architecture of Tissue Analysis), a differential-geometric framework that constructs continuous regulon activity fields from transcript coordi...

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Literature Corpus work
755458a8-6005-5688-9035-442269a8e033
DOI
10.64898/2026.02.24.707661
Open publication

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STRATA: Spatial Regulon Field Theory Reveals Coupling Architecture of Human Skin and Its Homogenization in MelanomaDOI 10.64898/2026.02.24.707661
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