Article

A deep learning framework for high-throughput mechanism-driven phenotype compound screening

2020-07-20

Abstract excerpt

<h4>ABSTRACT</h4> Target-based high-throughput compound screening dominates conventional one-drug-one-gene drug discovery process. However, the readout from the chemical modulation of a single protein is poorly correlated with phenotypic response of organism, leading to high failure rate in drug development. Chemical-induced gene expression profile provides an attractive solution to phenotype-based screening. How...

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Literature Corpus work: 2de0fe09-6885-5413-92f9-a74a36b6bcd0
DOI: 10.1101/2020.07.19.211235

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