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Article

The B.1.427/1.429 (epsilon) SARS-CoV-2 variants are more virulent than ancestral B.1 (614G) in Syrian hamsters.

PLoS pathogens - 1 Feb 2022

Carroll Timothy, Fox Douglas, van Doremalen Neeltje, Ball Erin, Morris Mary Kate, Sotomayor-Gonzalez Alicia, Servellita Venice, Rustagi Arjun, Yinda Claude Kwe, Fritts Linda, Port Julia Rebecca, Ma Zhong-Min, Holbrook Myndi G, Schulz Jonathan, Blish Catherine A, Hanson Carl, Chiu Charles Y, Munster Vincent, Stanley Sarah, Miller Christopher J

Abstract excerpt

As novel SARS-CoV-2 variants continue to emerge, it is critical that their potential to cause severe disease and evade vaccine-induced immunity is rapidly assessed in humans and studied in animal models. In early January 2021, a novel SARS-CoV-2 variant designated B.1.429 comprising 2 lineages, B.1.427 and B.1.429, was originally detected in California (CA) and it was shown to have enhanced infectivity in vitro...

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PMID: 35143587
DOI: 10.1371/journal.ppat.1009914
PMCID: PMC8865701

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