Article

Engineering Immunosuppressive Drug Resistant Armored (IDRA) SARS-CoV-2 T cells for cell therapy

2023-04-04

Abstract excerpt

<title>Abstract</title> <p>Solid organ transplant (SOT) recipients receive immunosuppressive drugs (ISDs) and are susceptible to develop severe COVID-19. Here, we analyzed the Spike-specific T cell response after 3 doses of mRNA vaccine in a group of SOT patients (<italic>n=136</italic>) treated with different ISDs. We demonstrated that combination of calcineurin inhibitor (CNI), mycophenolate mofetil (MMF), and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 74c3fcd3-2b0f-58c5-b5f4-2f1ea8d00e37
DOI: 10.21203/rs.3.rs-2745832/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Engineering Immunosuppressive Drug Resistant Armored (IDRA) SARS-CoV-2 T cells for cell therapyDOI 10.21203/rs.3.rs-2745832/v1Read

Cellular and Humoral Responses to SARS-CoV-2 Vaccination in Immunosuppressed PatientsSemantic proximity Read

T Cell Responses Induced by SARS-CoV-2 mRNA Vaccination Are Associated With Clonal ReplacementSemantic proximity Read

B and T cell responses after a third dose of SARS-CoV-2 vaccine in Kidney Transplant RecipientsSemantic proximity Read

Humoral immune responses against SARS-CoV-2 variants including omicron in solid organ transplant recipients after three doses of a COVID-19 mRNA vaccineSemantic proximity Read

Generation of glucocorticoid-resistant SARS-CoV-2 T cells for adoptive cell therapySemantic proximity Read

SARS-CoV-2 T-Cell Responses in Allogeneic Hematopoietic Stem Cell Recipients following Two Doses of BNT162b2 mRNA VaccineSemantic proximity Read

Lipid-Oxidizing B Cells Enable Successful Vaccine Response Despite ImmunosuppressionSemantic proximity Read

Immunotherapy with adoptive cytomegalovirus‐specific T cells transfer: Summarizing latest gene engineering techniquesSemantic proximity Read

Efficient Targeted Delivery of Bifunctional Circular Aptamer ASO Chimera to Suppress the SARS-CoV-2 Proliferation and InflammationSemantic proximity Read

Alternative Strategies to Increase the Immunogenicity of Covid-19 Vaccines in Kidney Transplant Recipients Not Responding to Two or Three Doses of an mRNA Vaccine. A Randomized Clinical TrialSemantic proximity Read

SARS-CoV-2 Vaccines in Patients With Multiple MyelomaSemantic proximity Read

Impact of Maintenance Immunosuppression Regimen on Anti-SARS-CoV-2 Antibody Kinetics In Kidney Transplant Recipients Receiving ChAdOx1 as Primary VaccinationSemantic proximity Read