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Mechanism of non-coding RNA regulation of DNMT3A and its relation to histones, regulatory proteins, and clinically relevant mutations

2024-10-07

Abstract excerpt

<title>Abstract</title> <p><bold>Background </bold><italic>De novo</italic> DNA methylation by DNMT3A is a fundamental epigenetic modification for transcriptional regulation. Histone tails and regulatory proteins regulate DNMT3A, and the crosstalk between these epigenetic mechanisms ensures appropriate DNA methylation patterning. Based on findings showing that <italic>Fos</italic>ecRNA inhibits DNMT3A activity in...

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Literature Corpus work
74a45b8d-8ffa-5f77-9b96-a4dcc56b48f5
DOI
10.21203/rs.3.rs-5026595/v1
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