Substance P enhances doxorubicin (Adriamycin)-associated autophagy and reduces cardiomyocyte apoptosis

Abstract excerpt

<h4>Background: </h4> Anthracyclines, including doxorubicin, are some of the most potent anticancer drugs available. However, the use of doxorubicin as a chemotherapeutic agent is severely hindered by dose-limiting toxicity, particularly cardiotoxicity, while degrading other organ systems. Despite years of use and the number of details published on this drug, the understanding of its cellular mechanisms remains li...

Topics

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• ATP Synthase and ATPases Research
• Autophagy in Disease and Therapy
• Calcium signaling and nucleotide metabolism
• Cancer-related cognitive impairment studies
• Cardiac Ischemia and Reperfusion
• Chemotherapy-induced cardiotoxicity and mitigation
• Inflammasome and immune disorders
• Mitochondrial Function and Pathology

Identifiers and source

Literature Corpus work

74928d10-9679-5afe-b6c7-546429cfd73f

DOI

10.21203/rs.3.rs-889196/v2