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A Study of the Molecular Mechanism by Which Substance P Enhances Doxorubicin (Adriamycin)-Associated Autophagy and Apoptosis of Cardiomyocytes Induces Heart Failure

2021-06-30

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Anthracyclines, including doxorubicin, are some of the most potent anticancer drugs available. However, the use of doxorubicin as a chemotherapeutic agent is severely hindered by dose-limiting toxicity, particularly cardiotoxicity, while degrading other organ systems. Despite years of use and the amount of details published on this drug, the understanding of its...

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Literature Corpus work: 5e98a20f-6065-59f5-8a8e-522280557e1c
DOI: 10.21203/rs.3.rs-659015/v1

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