Article

Axl-mediated activation of TBK1 drives epithelial plasticity in pancreatic cancer

2018-10-22

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDA) is characterized by an activating mutation in KRAS , which is critical for the biology of PDA progression. Direct inhibition of KRAS through pharmacological means remains a challenge; however, targeting key KRAS effectors has therapeutic potential. We investigated the contribution of TANK-binding kinase 1 (TBK1), a critical downstream effector of mutant active KRAS, to PDA p...

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Literature Corpus work: 747860cc-6fa4-5dbe-bd5a-58ae0e6c94c9
DOI: 10.1101/450049

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