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Rhythm profiling using COFE reveals multi-omic circadian rhythms in human cancers in vivo

27 May 2025

Abstract excerpt

The study of ubiquitous circadian rhythms in human physiology requires regular measurements across time. Repeated sampling of the different internal tissues that house circadian clocks is both practically and ethically infeasible. Here, we present a novel unsupervised machine learning approach (COFE) that can use single high-throughput omics samples (without time labels) from individuals to reconstruct circadian...

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PMID: 40424435
DOI: 10.1371/journal.pbio.3003196

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