Article

From Atoms to Neuronal Spikes: A Multi-Scale Simulation Framework

2025-11-07

Abstract excerpt

Understanding how molecular events in ion channels impact neuronal excitability, as derived from the calculation of the time course of the membrane potentials, can help elucidate the mechanisms of neurological disease-linked mutations and support neuroactive drug design. Here, we propose a multi-scale simulation approach which couples molecular simulations with neuronal simulations to predict the variations in mem...

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Literature Corpus work: 73d2d7ca-11e5-5c98-981c-e9743f90df85
DOI: 10.1101/2025.11.06.686996

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