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<i>ADP-ribose-acceptor hydrolase 2</i> ( <i>Arh2</i> ) deficiency results in cardiac dysfunction, tumorigenesis, inflammation, and decreased survival

2023-02-07

Abstract excerpt

ADP-ribosylation is a reversible reaction with ADP-ribosyltransferases catalyzing the forward reaction and ADP-ribose-acceptor hydrolases (ARHs) hydrolyzing the ADP-ribose acceptor bond. ARH2 is a member of the 39-kDa ARH family (ARH1-3), which is expressed in heart and skeletal muscle. ARH2 failed to exhibit any in vitro enzymatic activity. To determine its possible in vivo activities, Arh2 -knockout (KO) and -...

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Literature Corpus work
7390aaa1-a8e3-524e-97fa-5dd8f8ee87d9
DOI
10.1101/2023.02.07.527494
Open publication

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