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Article

The Effect of Heterozygous Mutation of Adenylate Kinase 2 Gene on Neutrophil Differentiation.

International journal of molecular sciences - 17 Dec 2022

Horiguchi Taigo, Tanimura Ayako, Miyoshi Keiko, Hagita Hiroko, Minami Hisanori, Noma Takafumi

Abstract excerpt

Mitochondrial ATP production plays an important role in most cellular activities, including growth and differentiation. Previously we reported that Adenylate kinase 2 (AK2) is the main ADP supplier in the mitochondrial intermembrane space in hematopoietic cells, especially in the bone marrow. AK2 is crucial for the production of neutrophils and T cells, and its deficiency causes reticular dysgenesis. However, the...

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Identifiers

PMID: 36555730
DOI: 10.3390/ijms232416089
PMCID: PMC9786915

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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