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Loss of interruption in the <i>HTT</i> CAG repeat is associated with increased somatic expansion and loss of medium spiny neurons in HD

2026-03-05

Abstract excerpt

Synonymous loss of interruption variants in the expanded CAG repeat sequence of Huntingtin ( HTT ) accelerate the clinical onset and progression of Huntington disease (HD). Medium spiny neurons (MSNs) are gradually lost in HD and undergo selective somatic CAG expansion, but it is unclear how CAG expansion in MSNs relates to HD pathology. Here, we show that MSNs with large (111-150 CAG) and very large (>150 CAG) s...

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Literature Corpus work
7351d576-8f03-5dec-a63c-a3d536da7b39
DOI
10.64898/2026.03.02.709181
Open publication

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Loss of interruption in the <i>HTT</i> CAG repeat is associated with increased somatic expansion and loss of medium spiny neurons in HDDOI 10.64898/2026.03.02.709181
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