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Article

In-Silico Evaluation of Genetic Alterations in Ovarian Carcinoma and Therapeutic Efficacy of NSC777201, as a Novel Multi-Target Agent for TTK, NEK2, and CDK1.

International journal of molecular sciences - 31 May 2021

Khedkar Harshita Nivrutti, Wang Yu-Chi, Yadav Vijesh Kumar, Srivastava Prateeti, Lawal Bashir, Mokgautsi Ntlotlang, Sumitra Maryam Rachmawati, Wu Alexander T H, Huang Hsu-Shan

Abstract excerpt

Ovarian cancer is often detected at the advanced stages at the time of initial diagnosis. Early-stage diagnosis is difficult due to its asymptomatic nature, where less than 30% of 5-year survival has been noticed. The underlying molecular events associated with the disease's pathogenesis have yet to be fully elucidated. Thus, the identification of prognostic biomarkers as well as developing novel therapeutic...

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PMID: 34072728
DOI: 10.3390/ijms22115895
PMCID: PMC8198179

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