Article

Using the Immunophenotype to Predict Response to Biologic Drugs in Rheumatoid Arthritis

2019-08-23

Abstract excerpt

Tumour necrosis factor-α is a key mediator of inflammation in rheumatoid arthritis its discovery led to the development of highly successful anti-TNF therapy. Subsequently, other biologic drugs targeting immune pathways, namely interleukin-6 blockade, B cell depletion, and T cell co-stimulation blockade, have been developed. Not all patients respond to a biologic drug leading to a knowledge gap between biolo...

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Literature Corpus work: 7234ea82-b490-59aa-a6b0-59c467f5a3ae
DOI: 10.20944/preprints201908.0242.v1

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