Back to search

Article

The Proteomic Profiles of Leukocyte-Rich Platelet-Rich Plasma-Derived Small Extracellular Vesicles Differ Between Responders and Non-Responders Treated for Knee Osteoarthritis

2026-02-11

Abstract excerpt

Intra-articular injection of autologous Platelet Rich-Platelet Plasma (PRP) is commonly employed as a non-surgical option for treating early-stage knee osteoarthritis (OA). Placebo-controlled clinical trials show sustained improvements in knee pain and function in most, but not all patients. Although several hypotheses have been put forward, the reasons for inconsistent responses remain unclear. Exosomes, a class...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
7223ffdb-6c9c-5268-884f-534252b7323f
DOI
10.20944/preprints202602.0879.v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The Proteomic Profiles of Leukocyte-Rich Platelet-Rich Plasma-Derived Small Extracellular Vesicles Differ Between Responders and Non-Responders Treated for Knee OsteoarthritisDOI 10.20944/preprints202602.0879.v1
Synovial Fluid Extracellular Vesicles from Patients with Severe Osteoarthritis Differentially Promote a Pro-Catabolic, Inflammatory Chondrocyte PhenotypeSemantic proximity
Synovial Fluid Extracellular Vesicles from Patients with Severe Osteoarthritis Differentially Promote a Pro-Catabolic, Inflammatory Chondrocyte Phenotype.Semantic proximity
The Application of Extracellular Vesicles Mediated miRNAs in Osteoarthritis: Current Knowledge and PerspectiveSemantic proximity
Small extracellular vesicles from mesenchymal stromal cells: the next therapeutic paradigm for musculoskeletal disordersSemantic proximity
Extracecellulr vesicles (EVs) microRNAs (miRNAs) derived from mesenchymal stem cells (MSCs) in osteoarthritis (OA); detailed role in pathogenesis and possible therapeuticsSemantic proximity
Unveiling the functional heterogeneity of endogenous tissue extracellular vesicles in skeletal muscle through multi-omicsSemantic proximity
iTRAQ proteomic analysis of exosomes derived from synovial fluid reveals disease patterns and potential biomarkers of OsteoarthritisSemantic proximity
Temporal Extracellular Vesicle Protein Changes following Intraarticular Treatment with Integrin α10β1-selected Mesenchymal Stem Cells in Equine OsteoarthritisSemantic proximity
Small Extracellular Vesicles by Nucleus Pulposus Cells Maintain Niche and Cell Homeostasis via Receptor Shuffling and Metabolic Enzyme SupplementsSemantic proximity
Identification and proteomic profiling of CD90 <sup>+</sup> small EVs using a refined immunocapture separation approach targeting stromal-derived EV subpopulations in synovial fluid of arthritis patientsSemantic proximity
Unlocking the potential of exosomes: a breakthrough in the theranosis of degenerative orthopaedic diseasesSemantic proximity
Extracellular vesicle bioactivity and potential clinical utility is determined by mesenchymal stromal cell clonal subtypeSemantic proximity
Select a neighboring publication to make it the new centre.