Article

IFN-γ Increases the Severity and Accelerates the Onset of Experimental Autoimmune Uveitis in Transgenic Rats

1999-01-01

Abstract excerpt

Abstract Experimental autoimmune uveitis (EAU) is a predominantly Th1-mediated intraocular inflammatory disease that serves as a model for studying the immunopathogenic mechanisms of uveitis and organ-specific autoimmune diseases. Despite the well-documented role of IFN-γ in the activation of inflammatory cells that mediate autoimmune pathology, recent studies in IFN-γ-deficient mice paradoxically show that IFN-γ...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 71e5b98f-575e-5b6b-b149-21b7e9845a7d
DOI: 10.4049/jimmunol.162.1.510

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

IFN-γ Increases the Severity and Accelerates the Onset of Experimental Autoimmune Uveitis in Transgenic RatsDOI 10.4049/jimmunol.162.1.510Read

Mouse models of experimental autoimmune uveitis.Semantic proximity Read

Patterns of Inflammation in Experimental Autoimmune Uveitis and Their Correlation to Optical Coherence Tomography Findings in Human UveitisSemantic proximity Read

A pathogenic CD4 T cell phenotype in experimental uveitis shares common features with other immune mediated inflammatory diseasesSemantic proximity Read

Severe chronic experimental autoimmune uveitis (EAU) of the C57BL/6 mouse induced by adoptive transfer of IRBP1-20-specific T cells.Semantic proximity Read

Green tea catechins alleviate autoimmune symptoms and visual impairment in a murine model for human chronic intraocular inflammation by inhibiting Th17-associated pro-inflammatory gene expressionSemantic proximity Read

EXPERIMENTAL AUTOIMMUNE UVEITIDES: MULTIPLE ANTIGENS, DIVERSE DISEASESSemantic proximity Read

Dual Function of the IRF8 Transcription Factor in Autoimmune Uveitis: Loss of IRF8 in T Cells Exacerbates Uveitis, Whereas <i>Irf8</i> Deletion in the Retina Confers ProtectionSemantic proximity Read

Fas and Fas ligand expressed on cells of the immune system, not on the target tissue, control induction of experimental autoimmune uveitis.Semantic proximity Read

TMP778, a selective inhibitor of RORγt, suppresses experimental autoimmune uveitis development, but affects both Th17 and Th1 cell populationsSemantic proximity Read

Common genetic determinants of uveitis shared with other autoimmune disorders.Semantic proximity Read

Regulation, counter-regulation, and immunotherapy of autoimmune responses to immunologically privileged retinal antigens.Semantic proximity Read

Uveitis-associated epitopes of retinal antigens are pathogenic in the humanized mouse model of uveitis and identify autoaggressive T cells.Semantic proximity Read