Article

Expression of CFTR, a hallmark gene of ionocyes, is downregulated in salivary glands of Sjögren’s syndrome patients

2022-09-19

Abstract excerpt

<h4>Introduction: </h4> The autoimmune exocrinopathy, Sjögren’s syndrome (SjS), is associated with secretory defects in salivary glands. The cystic fibrosis transmembrane conductance regulator (CFTR) of the chloride channel is a master regulator of fluid secretion, but its role in SjS has not been investigated. Our research found a link between CFTR and SjS at the genetic and protein levels, as well as through cli...

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Identifiers and source

Literature Corpus work: 71b06ade-67ca-590c-a359-a5b968d35cc9
DOI: 10.21203/rs.3.rs-2041802/v1

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