Article

Transcriptional Network Governing the Angiogenic Switch in Human Pancreatic Cancer

2008-01-01

Abstract excerpt

A shift of the angiogenic balance to the proangiogenic state, termed the “angiogenic switch,” is a hallmark of cancer progression. Here we devise a strategy for identifying genetic participants of the angiogenic switch based on inverse regulation of genes in human endothelial cells in response to key endogenous pro- and antiangiogenic proteins. This approach reveals a global network pattern for vascular homeostasi...

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Literature Corpus work: 71a6ef2f-c6c9-5728-93ea-4d0695d2bffc
DOI: 10.3731/topologica.1.016

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