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Article

Apoptotic metabolites ameliorate bone aging phenotypes via TCOF1/FLVCR1-mediated mitochondrial homeostasis.

Journal of nanobiotechnology - 6 Sept 2024

Qu Yan, Meng Bowen, Cai Simin, Yang Benyi, He Yifan, Fu Chaoran, Li Xiangxia, Li Peiyi, Cao Zeyuan, Mao Xueli, Teng Wei, Shi Songtao

Abstract excerpt

Over 50 billion cells undergo apoptosis each day in an adult human to maintain tissue homeostasis by eliminating damaged or unwanted cells. Apoptotic deficiency can lead to age-related diseases with reduced apoptotic metabolites. However, whether apoptotic metabolism regulates aging is unclear. Here, we show that aging mice and apoptosis-deficient MRL/lpr (B6.MRL-Faslpr/J) mice exhibit decreased apoptotic levels...

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Source

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Identifiers

PMID: 39237990
DOI: 10.1186/s12951-024-02820-x
PMCID: PMC11378613

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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