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Article

Development of an Oncolytic Influenza A Virus Vector Expressing Human CXCL10 for Enhanced T-Cell Responses

2025-12-12

Abstract excerpt

Influenza A virus (IAV) vectors with truncated NS1 proteins combine strong innate adjuvanticity with genetic flexibility and are attractive platforms for immune modulation. We engineered an NS1-truncated A/Puerto Rico/8/34 (H1N1) virus, PR8/NS124_SS_CXCL10, to express human CXCL10 from the NS segment and compared its biological and immunological properties with the parental NS124 vector in mice. The CXCL10-express...

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Identifiers and source

Literature Corpus work
716ef3b6-cfe1-5636-b900-227ffed2b255
DOI
10.20944/preprints202512.1195.v1
Open publication

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Development of an Oncolytic Influenza A Virus Vector Expressing Human CXCL10 for Enhanced T-Cell ResponsesDOI 10.20944/preprints202512.1195.v1
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