Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeted gene panel provides advantages over whole-exome sequencing for diagnosing obesity and diabetes mellitus.

Journal of molecular cell biology - 27 Nov 2023

Yu Hairong, Yu Haoyong, Zhang Rong, Peng Danfeng, Yan Dandan, Gu Yunjuan, Bao Yuqian, Jia Weiping, Zhang Hong, Hu Cheng

Abstract excerpt

A small fraction of patients diagnosed with obesity or diabetes mellitus has an underlying monogenic cause. Here, we constructed a targeted gene panel consisting of 83 genes reported to be causative for monogenic obesity or diabetes. We performed this panel in 481 patients to detect causative variants and compared these results with whole-exome sequencing (WES) data available for 146 of these patients. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes Mellitus
Share to Diet and metabolism studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Exome Sequencing

Share to Genetic Associations and Epidemiology

Share to Mutation

Share to Obesity

Share to Pancreatic function and diabetes

Source

Open in PubMed Open full text

Identifiers

PMID: 37327085
DOI: 10.1093/jmcb/mjad040
PMCID: PMC10847719

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeted gene panel provides advantages over whole-exome sequencing for diagnosing obesity and diabetes mellitus.PMID 37327085Read ↗

Detecting monogenic obesity: a systematic exome-wide workup of over 500 individuals.Semantic proximity Read ↗

Detecting Monogenic Obesity: A Systematic Exome-Wide Workup of Over 500 IndividualsSemantic proximity Read ↗

Identifying Pathogenic Variants of Monogenic Diabetes Using Targeted Panel Sequencing in an East Asian PopulationSemantic proximity Read ↗

Genetic obesity: next-generation sequencing results of 1230 patients with obesity.Semantic proximity Read ↗

Highly sensitive diagnosis of 43 monogenic forms of diabetes or obesity through one-step PCR-based enrichment in combination with next-generation sequencing.Semantic proximity Read ↗

Sequencing methods, functional characterization, prevalence, and penetrance of rare coding mutations in panels of monogenic obesity genes from the leptin-melanocortin pathway: A systematic review.Semantic proximity Read ↗

Precision medicine for monogenic diabetes: from a survey to the development of a next-generation diagnostic panel.Semantic proximity Read ↗

Identification of candidate gene variants of monogenic diabetes using targeted panel sequencing in early onset diabetes patients.Semantic proximity Read ↗

Phenotypic heterogeneity in monogenic diabetes: the clinical and diagnostic utility of a gene panel-based next-generation sequencing approach.Semantic proximity Read ↗

Combined analysis of whole-exon sequencing and lncRNA sequencing in type 2 diabetes mellitus patients with obesity.Semantic proximity Read ↗

Review of current status of molecular diagnosis and characterization of monogenic diabetes mellitus: a focus on next-generation sequencing.Semantic proximity Read ↗

Updates on Rare Genetic Variants, Genetic Testing, and Gene Therapy in Individuals With Obesity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.