Article

SPEAK: Spatial Prompting with Expert Aligned Knowledge for Tissue Domain Identification in Spatial Transcriptomics

2026-06-26

Abstract excerpt

Spatially resolved transcriptomic (SRT) data requires spatial domain identification to enable tissue microenvironment-specific downstream analyses. Here we present SPEAK (Spatial Prompting with Expert-Aligned Knowledge), a large language model (LLM)-based method to identify spatial domains from SRT data by taking advantage of the prior knowledge from both LLM and human experts. SPEAK constructs a spatial context p...

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Literature Corpus work: 70adf3f2-a0cc-5678-b823-409e68897344
DOI: 10.64898/2026.06.22.733750

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