Article

SHP2 inhibition enhances the anticancer effect of Osimertinib in EGFR T790M mutant lung adenocarcinoma by blocking CXCL8 loop mediated stemness

2021-03-04

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Additional epidermal growth factor receptor (EGFR) mutations confer the drug resistance to generations of EGFR targeted tyrosine kinase inhibitor (EGFR-TKI), which is the thorny challenge to propel the treatment of lung adenocarcinoma (LUAD) forward. In the tailored targeting era, the strategy of EGFR-TKI combined regimen was considered the promising approach to...

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Literature Corpus work: 6fa97c3c-591d-5c0e-9e07-76ffcba502cf
DOI: 10.21203/rs.3.rs-262045/v1

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