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Autophagy determines osimertinib resistance through regulation of stem cell-like properties in EGFR-mutant lung cancer

2018-05-24

Abstract excerpt

<h4>ABSTRACT</h4> Drug resistance to Osimertinib, a 3 rd -generation EGFR-TKI is inevitable. Autophagy plays a contradictory role in resistance of 1 st and 2 nd generation EGFR-TKI, and its significance in osimertinib resistance is much less clear. We therefore investigated whether autophagy determines osimertinib resistance. First, osimertinib induced autophagy to a much greater extent than that of gefitinib,...

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Literature Corpus work
a4ab64e9-c5d6-54de-9276-0a95a297a586
DOI
10.1101/330092
Open publication

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