Article

Hormonal and Behavioral Consequences of Social Isolation and Loneliness: Neuroendocrine Mechanisms and Clinical Implications

2025-11-17

Abstract excerpt

Social isolation and loneliness represent critical psychosocial stressors associated with profound hormonal dysregulation and adverse behavioral outcomes. This review synthesizes current evidence on the neuroendocrine mechanisms linking perceived and objective social disconnection to health consequences, with emphasis on hypothalamic-pituitary-adrenal (HPA) axis dysfunction, altered glucocorticoid signaling, and i...

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Literature Corpus work: 6eb1a123-91cc-5656-97ca-9e5245c1fba7
DOI: 10.20944/preprints202511.1132.v1

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