Article

The RNA demethylase FTO controls m <sup>6</sup> A marking on SARS-CoV-2 and classifies COVID-19 severity in patients

2022-06-28

Abstract excerpt

The RNA modification N 6 -methyladenosine (m 6 A) plays a key role in the life cycles of several RNA viruses. Whether this applies to SARS-CoV-2 and whether m 6 A affects the outcome of COVID-19 disease is still poorly explored. Here we report that the RNA demethylase FTO strongly affects both m 6 A marking of SARS-CoV-2 and COVID-19 severity. By m 6 A profiling of SARS-CoV-2, we confirmed in infected culture...

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Literature Corpus work: 6e029a30-29c5-57e4-aebd-107f9518ac91
DOI: 10.1101/2022.06.27.497749

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