Article

Hydrophobic tails enable diverse functions of the extracellular chaperone clusterin

2024-10-31

Abstract excerpt

Clusterin, a conserved secretory glycoprotein abundant in blood plasma and cerebrospinal fluid, functions as a molecular chaperone and apolipoprotein (Wyatt et al. 2013, Raulin et al. 2022). Dysregulation of clusterin is linked to late-onset Alzheimer’s disease, cardiovascular pathology and cancer (Rohne et al. 2016, Satapathy and Wilson 2021, Wilson et al. 2023). Despite its prominent role in extracellular proteo...

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Literature Corpus work: 6d1447b0-65bd-541c-ace8-e44c467c3b44
DOI: 10.1101/2024.10.30.620894

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