Article

Evaluation of Compatibility of 16S rRNA V3V4 and V4 Amplicon Libraries for Clinical Microbiome Profiling

2020-08-20

Abstract excerpt

<h4>ABSTRACT</h4> Sequencing of the 16S rRNA gene by Illumina next-generation sequencing is broadly used in microbiome studies. Different hypervariable regions of the 16S rRNA gene, V3V4 (amplified with primers 341F–805R) or V4 (V4O; primers 515F–806R), are selected, depending on the targeted resolution. However, in population-based clinical studies, combining V3V4 and V4 data from different studies for a meta-an...

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Literature Corpus work: 6d01a661-3823-5b1a-86a5-cfd06f8636dd
DOI: 10.1101/2020.08.18.256818

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