Article

A natural variant and an engineered mutation in a GPCR promote DEET resistance in <i>C. elegans</i>

2017-10-05

Abstract excerpt

DEET (N,N-diethyl-meta-toluamide) is a synthetic chemical, identified by the United States Department of Agriculture in 1946 in a screen for repellents to protect soldiers from mosquito-borne diseases 1,2 . Since its discovery, DEET has become the world’s most widely used arthropod repellent 3 , and is effective against invertebrates separated by millions of years of evolution, including biting flies 4 , honeyb...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6c3545e3-5f76-53ab-9e0d-a481c33a49ca
DOI: 10.1101/198705

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A natural variant and an engineered mutation in a GPCR promote DEET resistance in <i>C. elegans</i>DOI 10.1101/198705Read

An efficient behavioral screening platform classifies natural products and other chemical cues according to their chemosensory valence in <i>C. elegans</i>Semantic proximity Read

Behavioural and genetic evidence for C. elegans' ability to detect volatile chemicals associated with explosives.Semantic proximity Read

A conserved behavioral role for a nematode interneuron neuropeptide receptor.Semantic proximity Read

Multiparameter behavioral profiling reveals distinct thermal response regimes in Caenorhabditis elegans.Semantic proximity Read

FMRFamide-like peptides expand the behavioral repertoire of a densely connected nervous system.Semantic proximity Read

A Forward Genetic Screen for Molecules Involved in Pheromone-Induced Dauer Formation in Caenorhabditis elegans.Semantic proximity Read

Anthelmintic drug actions in resistant and susceptible C. elegans revealed by electrophysiological recordings in a multichannel microfluidic device.Semantic proximity Read

Alternatives to mammalian pain models 1: use of C. elegans for the study of volatile anesthetics.Semantic proximity Read

TAXISCAN, Optimizing throughput and behavioral depth in standard <i>C. elegans</i> chemotaxis assaysSemantic proximity Read

Mechanisms of DEET gustation in Drosophila.Semantic proximity Read

The neuronal GPCR OCTR-1 mediates temperature effects on longevity by regulating immune response genes in <i>C. elegans</i>Semantic proximity Read

Early Developmental Exposure to Volatile Anesthetics Causes Behavioral Defects in Caenorhabditis elegansSemantic proximity Read