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Therapeutically targetable Th17-derived miR-721 drives autoimmune myocarditis through PPARγ repression

2026-03-26

Abstract excerpt

<h4>BACKGROUND</h4> Myocarditis is an inflammatory cardiac disease in which Th17-driven immune responses contribute to progression toward dilated cardiomyopathy and heart failure. Current therapies mainly rely on corticosteroids but lack specificity, while the role of miR-721, synthesized by Th17 cells, remains largely unexplored in disease pathogenesis. <h4>METHODS</h4> We characterized the presence of mmu-miR-...

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Literature Corpus work
6c2cf7ec-7bab-5a35-b727-a34af10deabb
DOI
10.64898/2026.03.24.713340
Open publication

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Therapeutically targetable Th17-derived miR-721 drives autoimmune myocarditis through PPARγ repressionDOI 10.64898/2026.03.24.713340
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