Article

Transcriptional landscape of DNA repair genes underpins a pan-cancer prognostic signature associated with cell cycle dysregulation and tumor hypoxia

2019-01-13

Abstract excerpt

Overactive DNA repair contributes to therapeutic resistance in cancer. However, pan-cancer comparative studies investigating the contribution of all DNA repair genes in cancer progression employing an integrated approach have remained limited. We performed a multicohort retrospective analysis to determine the prognostic significance of 138 DNA repair genes in 16 cancer types (n=16,225). Cox proportional hazards a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6c27038e-c989-59eb-8214-bea13e4e77d2
DOI: 10.1101/519603

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transcriptional landscape of DNA repair genes underpins a pan-cancer prognostic signature associated with cell cycle dysregulation and tumor hypoxiaDOI 10.1101/519603Read

A novel signature derived from immunoregulatory and hypoxia genes predicts prognosis in liver and five other cancersSemantic proximity Read

Dual prognostic role for 2-oxoglutarate oxygenases in ten diverse cancer types: Implications for cell cycle regulation and cell adhesion maintenanceSemantic proximity Read

DNA Repair Gene Expression Adjusted by the PCNA Metagene Predicts Survival in Multiple CancersSemantic proximity Read

The Human Pathology Atlas for deciphering the prognostic features of human cancersSemantic proximity Read

Identification of a Hypoxia-Related Gene Model for Predicting the Prognosis and Formulating the Treatment Strategies in Kidney Renal Clear Cell CarcinomaSemantic proximity Read

DNA Repair Gene Expression Adjusted by the PCNA Metagene Predicts Survival in Multiple CancersSemantic proximity Read

DNA damage repair-related gene signature can influence immune status and predict prognosis in hepatocellular carcinomaSemantic proximity Read

Genomic landscape of DNA repair genes in cancerSemantic proximity Read

Derivation of a fifteen gene prognostic panel for six cancers.Semantic proximity Read

Pan-urologic cancer genomic subtypes that transcend tissue of origin.Semantic proximity Read

Landscape of cancer diagnostic biomarkers from specifically expressed genesSemantic proximity Read

A Gene Signature for Selecting Benefit from Hypoxia Modification of Radiotherapy for High-Risk Bladder Cancer PatientsSemantic proximity Read