Article

Oral adrenergic agents produced Ventricular fibrillation and QT prolongation in an elderly patient carrying an RYR2 variant.

2021-05-03

Abstract excerpt

Mutant cardiac ryanodine receptor channels (RyR2) are “leaky,” and spontaneous Ca2+ release through these channels causes delayed afterdepolarizations that can deteriorate into ventricular fibrillation (VF). RYR2 is a causative gene of type 1 catecholaminergic polymorphic ventricular tachycardia (CPVT). Some patients carrying RYR2 mutations in CPVT exhibit QT prolongation and are initially diagnosed with long QT s...

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Literature Corpus work: 6bd76152-1b55-5f2b-a106-4e60ab4c3984
DOI: 10.22541/au.162005798.84941643/v1

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