X-ray Irradiation activates immune response in human T-lymphocytes by eliciting a Ca ²⁺ signaling cascade

Abstract excerpt

Radiation therapy is efficiently employed for eliminating cancer cells and reducing tumor growth. To further improving its therapeutic application it is mandatory to unravel the molecular effects of ionizing irradiation and to understand whether they support or counteract tumor therapy. Here we examine the impact of X-ray irradiation on immune activation of human T cells with single doses typically employed in tum...

Topics

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• Bystander Effect
• Cell Culture Techniques
• Cell Line
• DNA Repair
• Effects of Radiation Exposure
• Ion Channels and Receptors
• Models, Biological
• Radiation, Ionizing

Identifiers and source

Literature Corpus work

6bd218f3-289a-5010-897c-ccfa73e2e14c

DOI

10.1101/2020.11.13.379982