Article

A ligand/receptor trafficking clock governs self-renewal and abscission dynamics in pluripotent stem cells

2025-12-23

Abstract excerpt

<h4>Summary/Abstract</h4> How extracellular cues are temporally integrated to regulate self-renewal and differentiation propensities across the cell cycle remains largely unresolved. We identify a ligand/receptor trafficking clock in rodent and human pluripotent stem cells (PSCs) in which the cyclic turnover of Netrin-1 and its receptors Neo1 and Unc5b (NNU) governs self-renewal capacity and abscission dynamics....

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Literature Corpus work: 6a8a3049-a9d3-553b-b01a-03a9ed4f8746
DOI: 10.64898/2025.12.22.695902

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