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Article

Exploring Target-Based Screening, Molecular Dynamics Simulation and Principal Component Analysis for Drug Repurposing in NUT Midline Carcinoma

2025-10-16

Abstract excerpt

<title>Abstract</title> <p> <bold>Purpose:</bold> NMC, a particularly malignant and invasive cancer resulting from the fusion of the NUT and BRD4 genes, yields a fusion protein that influences cell growth and regulates transcription. The deregulation of this protein has been documented in numerous cancerous conditions. The BD1 domain of BRD4-containing proteins has been demonstrated to bind to acetylated lysine...

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Literature Corpus work
69b5531f-d0b0-5b34-a191-04dc8fd9157f
DOI
10.21203/rs.3.rs-6601284/v1
Open publication

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