Defensive tolerance drives the reprogramming and dysfunction of infiltrating pathogenic B cells assuring the maintenance of tolerance

Abstract excerpt

<title>Abstract</title> <p>We previously showed that infiltrating cytotoxic immune cells are reprogrammed to regulatory-like/exhausted cells within accepted kidney allografts through a ‘defensive tolerance’ mechanism. We observed a regulatory B cell (Breg) signature within the accepted kidney. Here we show that despite a Breg phenotype, neither B cell depletion nor the use of μMT recipients which lack B cells, re...

Topics

Open a Topic to create a Post that cites this publication.

• Cancer Immunotherapy and Biomarkers
• Immune Cell Function and Interaction
• Immunotherapy and Immune Responses
• Kidney Transplantation
• Phenotype
• Renal Diseases and Glomerulopathies
• Renal Transplantation Outcomes and Treatments
• T-cell and B-cell Immunology

Identifiers and source

Literature Corpus work

6968d07b-2371-596c-8720-7cc79827b285

DOI

10.21203/rs.3.rs-7236564/v1