XIST lncRNA Knockdown Potentiates Dinaciclib-Induced Apoptosis in Acute myeloid leukemia via Bcl-2/NF-κB Axis Suppression

Abstract excerpt

<title>Abstract</title> <p>Background Acute myeloid leukemia (AML) is a diverse hematologic cancer marked by the clonal growth of immature hematopoietic cells and genetic abnormalities. Despite advances in chemotherapy, stem cell transplantation, and targeted therapies, patient outcomes continue to be poor because of therapeutic resistance and elevated relapse rates. Emerging research highlights the role of long...

Topics

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• Acute Myeloid Leukemia Research
• Cancer-related molecular mechanisms research
• Cell death mechanisms and regulation
• Histone Deacetylase Inhibitors Research
• Protein Degradation and Inhibitors
• RNA modifications and cancer
• Ubiquitin and proteasome pathways
• Viral-associated cancers and disorders

Identifiers and source

Literature Corpus work

6946fe63-fa8e-5859-b6da-61c611a578e8

DOI

10.21203/rs.3.rs-7393813/v1