HRCHY-CytoCommunity identifies hierarchical tissue organization in cell-type spatial maps

Abstract excerpt

Diverse cell types within a tissue assemble into multicellular structures to shape the functions of the tissue. These structural modules typically comprise specialized subunits, each performing unique roles. We present HRCHY-CytoCommunity, a graph neural network-based framework that leverages differentiable graph pooling and graph pruning to identify hierarchical multicellular structures in cell phenotype-annotate...

Topics

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• Algorithms
• Cluster Analysis
• Neural Networks, Computer
• Phenotype

Identifiers and source

Literature Corpus work

68fc2b9b-107c-56f0-856e-df7149ee882e

DOI

10.1101/2025.03.27.645631