Article

Pseudoachondroplasia is caused through both intra- and extracellular pathogenic pathways

2002-08-15

Abstract excerpt

Pseudoachondroplasia is a dominantly inherited chondrodysplasia associated with mutations in cartilage oligomeric matrix protein (COMP).Investigations into the pathogenesis of pseudoachondroplasia are hampered by its rarity.We developed a cell culture model by expressing mutant COMP in bovine primary chondrocytes using a gutless adenoviral vector.We show that mutant COMP exerts its deleterious effects through both...

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Literature Corpus work: 68e595d4-6c61-5eb8-b185-f4bda4123720
DOI: 10.1172/jci0214386

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