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Article

World Trade Center-Cardiorespiratory and Vascular Dysfunction: Assessing the Phenotype and Metabolome of a Murine Particulate Matter Exposure Model.

Scientific reports - 21 Feb 2020

Veerappan Arul, Oskuei Assad, Crowley George, Mikhail Mena, Ostrofsky Dean, Gironda Zakia, Vaidyanathan Sandhya, Wadghiri Youssef Zaim, Liu Mengling, Kwon Sophia, Nolan Anna

Abstract excerpt

Vascular changes occur early in the development of obstructive airways disease. However, the vascular remodeling and dysfunction due to World Trade Center-Particulate Matter (WTC-PM) exposure are not well described and are therefore the focus of this investigation. C57Bl/6 female mice oropharyngeally aspirated 200 µg of WTC-PM53 or phosphate-buffered saline (PBS) (controls). 24-hours (24-hrs) and 1-Month (1-M)...

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PMID: 32081898
DOI: 10.1038/s41598-020-58717-w
PMCID: PMC7035300

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