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Article

Semaphorin 3A and 3F Promote Lumen Expansion in TIE2-Mutated Venous Malformation.

Arteriosclerosis, thrombosis, and vascular biology - 1 Dec 2025

Schrenk Sandra, Sherpa Chhiring, Bischoff Lindsay J, Cai Yuqi, Boscolo Elisa

Abstract excerpt

BACKGROUND: Venous malformations (VMs) are developmental defects of the vasculature characterized by tremendously enlarged and dysfunctional veins. Gain-of-function somatic mutations in TIE2 (endothelial tyrosine kinase receptor) have been identified as the leading driver of VM pathogenesis. The aim of this study was to determine whether the aberrant venous lumen expansion is caused by recruitment of wild-type...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41127911
DOI: 10.1161/ATVBAHA.125.323387
PMCID: PMC12616615

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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