Article

Distinct Multimodal Imaging Correlates of Depression in Middle-Aged Adults With and Without a Family History of Alzheimer’s Disease

2026-04-17

Abstract excerpt

<h4>Background</h4> Depression is associated with risk for late-onset Alzheimer’s disease (LOAD), but its underlying pathogenesis in at-risk individuals remains unclear. We examined multimodal imaging correlates of depressive symptoms in cognitively normal middle-aged offspring of patients with LOAD (O-LOAD) compared with control individuals without LOAD history up to a 4 th degree of kinship (HC). <h4>Methods<...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6899e479-b695-5c27-a0d4-ca1cc7fb0dff
DOI: 10.64898/2026.04.13.717731

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Distinct Multimodal Imaging Correlates of Depression in Middle-Aged Adults With and Without a Family History of Alzheimer’s DiseaseDOI 10.64898/2026.04.13.717731Read

Common and distinct neural correlates of emotional processing in individuals at familial risk for major depressive disorder and bipolar disorder: A comparative meta-analysis.Semantic proximity Read

Hippocampal temporal dynamics and spatial heterogeneity unveil vulnerability markers in the offspring of bipolar patientsSemantic proximity Read

Amyloid-β and tau pathologies relate to distinctive brain dysconnectomics in preclinical autosomal dominant Alzheimer’s diseaseSemantic proximity Read

Polygenic Risk Score Effectively Predicts Risk of Depression Onset in Alzheimer’s DiseaseSemantic proximity Read

Polygenic Risk Score Effectively Predicts Depression Onset in Alzheimer’s Disease Based on Major Depressive Disorder Risk VariantsSemantic proximity Read

Alzheimer’s risk markers and resting-state dynamic functional connectivity: Cross-Sectional Findings from the AGUEDA StudySemantic proximity Read

Shared and Distinct Brain Regions in Anxiety, Depression, and Neuroticism: A Multi-Phenotypic Approach Using Data from the UK BiobankSemantic proximity Read

Multi-scale neural signatures of major depressive, anxiety, and stress-related disordersSemantic proximity Read

Localizing at-risk and early psychosis populations along data-driven clinical, cognitive, and neuroanatomical spectraSemantic proximity Read

Brain morphology mediating the effect of genetic risk variants on Alzheimer’s diseaseSemantic proximity Read

Parsing clinical and neurobiological sources of heterogeneity in depressionSemantic proximity Read

Whole-Cortex Mapping of Common Genetic Influences on Depression and Social DeficitsSemantic proximity Read